RO5166017

RO5166017
臨床資料
藥物類別	Trace amine-associated receptor 1 (TAAR1) partial or near-full agonist
識別資訊
	IUPAC命名法 (S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine; ;
CAS號	1048346-74-2
PubChem CID	25016538;
ChemSpider	34980944;
UNII	YK98JFQ52U;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID801030323 ;
化學資訊
化學式	C12H17N3O
摩爾質量	219.29 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES NC1=N[C@@H](CN(C2=CC=CC=C2)CC)CO1;
	InChI InChI=1S/C12H17N3O/c1-2-15(11-6-4-3-5-7-11)8-10-9-16-12(13)14-10/h3-7,10H,2,8-9H2,1H3,(H2,13,14)/t10-/m0/s1; Key:PPONHQQJLWPUPH-JTQLQIEISA-N;

RO5166017或RO-5166017是一種含氮有機化合物，化學式C
12H
17N
3O，屬於一種痕量胺相關受體 TAAR1的選擇性激動劑^[1]，由羅氏製藥研發^[2]。

參考文獻

^ Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, Metzler V, Chaboz S, Groebke Zbinden K, Galley G, Norcross RD, Tuerck D, Bruns A, Morairty SR, Kilduff TS, Wallace TL, Risterucci C, Wettstein JG, Hoener MC. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry. May 2013, 18 (5): 543–556. PMID 22641180. doi:10.1038/mp.2012.57.
^ Revel FG, Moreau JL, Gainetdinov RR, Bradaia A, Sotnikova TD, Mory R, Durkin S, Zbinden KG, Norcross R, Meyer CA, Metzler V, Chaboz S, Ozmen L, Trube G, Pouzet B, Bettler B, Caron MG, Wettstein JG, Hoener MC. TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc Natl Acad Sci U S A. May 2011, 108 (20): 8485–8490. Bibcode:2011PNAS..108.8485R. PMC 3101002 . PMID 21525407. doi:10.1073/pnas.1103029108 .