RO5166017

RO5166017
臨床資料
藥物類別	Trace amine-associated receptor 1 (TAAR1) partial or near-full agonist
识别信息
	IUPAC命名法 (S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine; ;
CAS号	1048346-74-2
PubChem CID	25016538;
ChemSpider	34980944;
UNII	YK98JFQ52U;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID801030323 ;
化学信息
化学式	C12H17N3O
摩尔质量	219.29 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES NC1=N[C@@H](CN(C2=CC=CC=C2)CC)CO1;
	InChI InChI=1S/C12H17N3O/c1-2-15(11-6-4-3-5-7-11)8-10-9-16-12(13)14-10/h3-7,10H,2,8-9H2,1H3,(H2,13,14)/t10-/m0/s1; Key:PPONHQQJLWPUPH-JTQLQIEISA-N;

RO5166017或RO-5166017是一种含氮有机化合物，化学式C
12H
17N
3O，属于一种痕量胺相关受体 TAAR1的选择性激动剂^[1]，由罗氏制药研发^[2]。

参考文献

^ Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, Metzler V, Chaboz S, Groebke Zbinden K, Galley G, Norcross RD, Tuerck D, Bruns A, Morairty SR, Kilduff TS, Wallace TL, Risterucci C, Wettstein JG, Hoener MC. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry. May 2013, 18 (5): 543–556. PMID 22641180. doi:10.1038/mp.2012.57.
^ Revel FG, Moreau JL, Gainetdinov RR, Bradaia A, Sotnikova TD, Mory R, Durkin S, Zbinden KG, Norcross R, Meyer CA, Metzler V, Chaboz S, Ozmen L, Trube G, Pouzet B, Bettler B, Caron MG, Wettstein JG, Hoener MC. TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc Natl Acad Sci U S A. May 2011, 108 (20): 8485–8490. Bibcode:2011PNAS..108.8485R. PMC 3101002 . PMID 21525407. doi:10.1073/pnas.1103029108 .