JWH-164

JWH-164
法律規範狀態
法律規範	美：附表I;
識別資訊
	IUPAC命名法 7-Methoxynaphthalen-1-yl-(1-pentylindol-3-yl)methanone; ;
CAS號	824961-61-7
PubChem CID	45271217;
ChemSpider	24618407;
UNII	L3432L6CJJ;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID70669880 ;
化學資訊
化學式	C25H25NO2
摩爾質量	371.48 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES CCCCCn(c4)c1ccccc1c4C(=O)c2cccc(cc3)c2cc3OC;
	InChI InChI=1S/C25H25NO2/c1-3-4-7-15-26-17-23(20-10-5-6-12-24(20)26)25(27)21-11-8-9-18-13-14-19(28-2)16-22(18)21/h5-6,8-14,16-17H,3-4,7,15H2,1-2H3; Key:IJNSZBAEVYRFCH-UHFFFAOYSA-N;

JWH-164，化學名N-正戊基-3-(7-甲氧基-1-萘甲酰基)吲哚，分子式C
25H
25NO
2，屬於萘甲酰基吲哚類JWH系列大麻素，是大麻素受體CB₁和CB₂的激動劑^[1]^[2]。它可以7-甲氧基-1-萘甲酸和N-戊基吲哚為原料經多步反應製得。^[3]

參考文獻

^ Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, et al. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists. Bioorganic & Medicinal Chemistry. January 2005, 13 (1): 89–112. PMID 15582455. doi:10.1016/j.bmc.2004.09.050.
^ Huffman JW, Padgett LW. Recent developments in the medicinal chemistry of cannabimimetic indoles, pyrroles and indenes. Current Medicinal Chemistry. 2005, 12 (12): 1395–411. PMID 15974991. doi:10.2174/0929867054020864.
^ Huffman, John W.; et al. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists. Bioorganic & Medicinal Chemistry (2004), 13 (1), 89-112. doi:10.1016/j.bmc.2004.09.050.