2,3-二巯基丙磺酸

2,3-二巯基丙磺酸
识别
CAS号	207233-91-8
PubChem	6321
ChemSpider	6081
SMILES	OS(=O)(=O)CC(S)CS;
InChI	1/C3H8O3S3/c4-9(5,6)2-3(8)1-7/h3,7-8H,1-2H2,(H,4,5,6);
InChIKey	JLVSRWOIZZXQAD-UHFFFAOYAD
ChEBI	888
KEGG	C10922
MeSH	Unithiol
性质
化学式	C3H8O3S3
摩尔质量	188.289 g/mol g·mol⁻¹
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

2,3-二巯基丙磺酸（英文缩写：DMPS），它的钠盐（商品名：Unithiol、Dimaval、螯金拔）作为螯合剂可以与多种重金属离子螯合，因此可以作为重金属中毒的解毒剂。合成2，3-二巯基丙磺酸的方法是由来自基辅的Petrunkin在1956年首先报道的^[1]，随后以Unithiol的药物名称列入苏联指定的官方药物^[2]^[3]。

参考资料

^ Petrunkin, V. E. Synthesis and properties of dimercapto derivatives of alkylsulfonic acids. 1: Synthesis of sodium 2, 3-dimercaptopropylsulfonate (unithiol) and sodium 2-mercaptoethylsulfonate.. Ukr. Khim. Zh. 1956, 22: 603–7.
^ Petrunkin, V. E. 1959. The synthesis of thiolic compounds as antidotes of arsenic and heavy metals. Tiolovye Soedinen. V. Med. Ukrain. NauchIssledovatel. Sanit-Khim Inst. Trudy Nauch. Konf. Kiev, 1957. pp. 7-18
^ Vasken Aposhian. DMSA and DMPS-water soluble antidotes for heavy metal poisoning.. Ann. Rev. Pharmacol Toxicol. 1983, 23: 193–213. PMID 6307120.

[1] Petrunkin, V. E. Synthesis and properties of dimercapto derivatives of alkylsulfonic acids. 1: Synthesis of sodium 2, 3-dimercaptopropylsulfonate (unithiol) and sodium 2-mercaptoethylsulfonate.. Ukr. Khim. Zh. 1956, 22: 603–7.

[2] Petrunkin, V. E. 1959. The synthesis of thiolic compounds as antidotes of arsenic and heavy metals. Tiolovye Soedinen. V. Med. Ukrain. NauchIssledovatel. Sanit-Khim Inst. Trudy Nauch. Konf. Kiev, 1957. pp. 7-18

[2-3] Vasken Aposhian. DMSA and DMPS-water soluble antidotes for heavy metal poisoning.. Ann. Rev. Pharmacol Toxicol. 1983, 23: 193–213. PMID 6307120.

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