鯊烯-藿烯環化酶

Squalene-hopene cyclase
	鯊烯-藿烯環化酶二聚體的晶體結構
命名
系統命名
縮寫
識別碼
EC編號	or 4/2/1/129.html 5.4.99.17
CAS號	76600-69-6
資料庫
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BRENDA（英語：BRENDA）	BRENDA入口
ExPASy（英語：ExPASy）	NiceZyme瀏覽
KEGG	KEGG入口
MetaCyc（英語：MetaCyc）	代謝路徑
PRIAM（英語：PRIAM_enzyme-specific_profiles）	概述
PDB	RCSB PDB PDBj PDBe PDBsum
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PMC	相關文獻
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鯊烯-藿烯環化酶（英語：Squalene-hopene cyclase，縮寫SHC，EC 5.4.99.17）或稱作藿烷-22-醇水裂解酶（hopan-22-ol hydro-lyase，EC 4.2.1.129）屬於原核生物中生成五環三萜的環化/變位酶家族，能催化下列兩種反應，生成藿烯或藿烷-22-醇，兩種產物的比例為5比1^[1]^[2]^[3]^[4]^[5]：

鯊烯

\rightleftharpoons

22(29)-藿烯

鯊烯 + H₂O

\rightleftharpoons

藿烷-22-醇

參考文獻

^ Hoshino T, Sato T. Squalene-hopene cyclase: catalytic mechanism and substrate recognition. Chemical Communications. February 2002, (4): 291–301. PMID 12120044. doi:10.1039/b108995c.
^ Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A. Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring. Organic & Biomolecular Chemistry. May 2004, 2 (10): 1456–70. PMID 15136801. doi:10.1039/b401172d.
^ Sato T, Kouda M, Hoshino T. Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius. Bioscience, Biotechnology, and Biochemistry. March 2004, 68 (3): 728–38. PMID 15056909. doi:10.1271/bbb.68.728.
^ Reinert DJ, Balliano G, Schulz GE. Conversion of squalene to the pentacarbocyclic hopene. Chemistry & Biology. January 2004, 11 (1): 121–6. PMID 15113001. doi:10.1016/j.chembiol.2003.12.013.
^ Pearson A, Budin M, Brocks JJ. Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus. Proceedings of the National Academy of Sciences of the United States of America. December 2003, 100 (26): 15352–7. PMC 307571 . PMID 14660793. doi:10.1073/pnas.2536559100.

外部連結

醫學主題詞表（MeSH）：Squalene-hopene+cyclase

[1] Hoshino T, Sato T. Squalene-hopene cyclase: catalytic mechanism and substrate recognition. Chemical Communications. February 2002, (4): 291–301. PMID 12120044. doi:10.1039/b108995c.

[2] Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A. Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring. Organic & Biomolecular Chemistry. May 2004, 2 (10): 1456–70. PMID 15136801. doi:10.1039/b401172d.

[3] Sato T, Kouda M, Hoshino T. Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius. Bioscience, Biotechnology, and Biochemistry. March 2004, 68 (3): 728–38. PMID 15056909. doi:10.1271/bbb.68.728.

[Reinert,_D.J.,_Balliano,_G._and_Schulz,_G.E._2004_121–126-4] Reinert DJ, Balliano G, Schulz GE. Conversion of squalene to the pentacarbocyclic hopene. Chemistry & Biology. January 2004, 11 (1): 121–6. PMID 15113001. doi:10.1016/j.chembiol.2003.12.013.

[Pearson,_A.,_Budin,_M.,_and_Brocks,_J._2003_15352–15357-5] Pearson A, Budin M, Brocks JJ. Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus. Proceedings of the National Academy of Sciences of the United States of America. December 2003, 100 (26): 15352–7. PMC 307571 . PMID 14660793. doi:10.1073/pnas.2536559100.

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閱論編異構酶：變位酶類（EC 5.4）
5.4.1：醯基變位酶	溶血卵磷脂醯基變位酶
5.4.2：磷酸變位酶	磷酸甘油酸變位酶二磷酸甘油酸變位酶磷酸葡糖變位酶磷酸甘露糖變位酶 PMM1 PMM2 磷酸烯醇式丙酮酸變位酶
5.4.99：其他基團	甲基丙二酸單醯輔酶A變位酶羊毛固醇合酶
EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 · 4.1/2/3/4/5/6 · 5.1/2/3/4/5/99 · 6.1-3（英語：Template:Ligases CO CS and CN）/4/5-6