曲克蘆丁

曲克蘆丁
臨床資料
其他名稱	Hydroxyethylrutoside (HER); Pherarutin; Trihydroxyethylrutin; 3',4',7-Tris[O-(2-hydroxyethyl)]rutin
AHFS/Drugs.com	國際藥品名稱
ATC碼	C05CA04 (WHO) ;
識別資訊
	IUPAC命名法 2-[3,4-bis(2-hydroxyethoxy)phenyl]-5-hydroxy-7-(2-hydroxyethoxy)-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-β-D-mannopyranosyl)-β-D-glucopyranoside; ;
CAS號	7085-55-4
PubChem CID	9896814;
ChemSpider	4589027 ;
UNII	7Y4N11PXO8;
KEGG	D07180;
ChEMBL	ChEMBL3182320 ;
化學資訊
化學式	C33H42O19
摩爾質量	742.68 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)Oc3c(=O)c4c(cc(cc4oc3c5ccc(c(c5)OCCO)OCCO)OCCO)O)O)O)O)O)O)O;
	InChI InChI=1S/C33H42O19/c1-14-23(38)26(41)28(43)32(49-14)48-13-21-24(39)27(42)29(44)33(51-21)52-31-25(40)22-17(37)11-16(45-7-4-34)12-20(22)50-30(31)15-2-3-18(46-8-5-35)19(10-15)47-9-6-36/h2-3,10-12,14,21,23-24,26-29,32-39,41-44H,4-9,13H2,1H3/t14-,21+,23-,24+,26+,27-,28+,29+,32+,33-/m0/s1 ; Key:IYVFNTXFRYQLRP-VVSTWUKXSA-N ;

曲克蘆丁（英語：Troxerutin）是一種有機化合物，化學式C
33H
42O
19，屬於羥乙基蘆丁，一類蘆丁（也叫芸香苷，是黃酮醇槲皮素與芸香二糖形成的糖苷）衍生物^[1]，存在於國槐（Styphnolobium japonicum）等植物中，可作為抗出血藥^[2]，能減少高膽固醇飲食引起的活性氧類^[3]。

參考文獻

^ Zhang ZF, Fan SH, Zheng YL, Lu J, Wu DM, Shan Q, Hu B. Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice. Biochemical Pharmacology. September 2014, 91 (1): 74–86. PMID 25026599. doi:10.1016/j.bcp.2014.07.002.
^ Riccioni C, Sarcinella R, Izzo A, Palermo G, Liguori M. [Effectiveness of Troxerutin in association with Pycnogenol in the pharmacological treatment of venous insufficiency]. Minerva Cardioangiologica. February 2004, 52 (1): 43–8. PMID 14765037.
^ Lu J, Wu DM, Zheng ZH, Zheng YL, Hu B, Zhang ZF. Troxerutin protects against high cholesterol-induced cognitive deficits in mice. Brain. March 2011, 134 (Pt 3): 783–97. PMID 21252113. doi:10.1093/brain/awq376 .