RTS,S

**RTS,S**
疫苗说明
目标	恶性疟原虫;较小程度的乙型肝炎
种类	蛋白质亚基疫苗
临床资料
商品名（英语：Drug nomenclature）	Mosquirix
给药途径	肌肉注射 (0.5 毫升)
法律规范状态
法律规范	处方药（℞-only）;
识别信息
CAS号	149121-47-1

RTS,S/AS01 (商业名称为Mosquirix)是一种基于重组蛋白的疟疾疫苗。它是唯一获得批准并广泛使用的疟疾疫苗。截至2022年4月 (2022-04)^[update]，该疫苗已为生活在中度至高度疟疾传播地区的100万名儿童接种，随着疫苗生产的扩大，还将提供数百万剂^[3]^[4]。2岁前的婴儿至少需接种三剂，第四剂可将保护再延长1至2年^[3]。该疫苗使严重疟疾住院的人数减少了约30%^[3]。

参考资料[编辑]

^ Mosquirix H-W-2300. European Medicines Agency (EMA). [4 March 2021]. （原始内容存档于2019-11-23）.
^ RTS,S Malaria Vaccine: 2019 Partnership Award Honoree. YouTube. Global Health Technologies Coalition. [6 October 2021].
^ ^3.0 ^3.1 ^3.2 First malaria vaccine hits 1 million dose milestone — although it has its shortcomings. NPR. 13 May 2022 [2 January 2023]. （原始内容存档于2022-11-13）.
^ Millions more children to benefit from malaria vaccine as UNICEF secures supply. UNICEF. 16 August 2022 [2 January 2023]. （原始内容存档于2023-01-02）（英语）.

延伸阅读[编辑]

Asante KP, Abdulla S, Agnandji S, Lyimo J, Vekemans J, Soulanoudjingar S, et al. Safety and efficacy of the RTS,S/AS01E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial. The Lancet. Infectious Diseases. October 2011, 11 (10): 741–9. PMID 21782519. doi:10.1016/S1473-3099(11)70100-1.
Wilby KJ, Lau TT, Gilchrist SE, Ensom MH. Mosquirix (RTS,S): a novel vaccine for the prevention of Plasmodium falciparum malaria. The Annals of Pharmacotherapy. March 2012, 46 (3): 384–93 [2023-04-21]. PMID 22408046. S2CID 32412123. doi:10.1345/aph.1AQ634. （原始内容存档于2021-10-27）.

外部链接[编辑]

Mosquirix: Product information （页面存档备份，存于互联网档案馆）
Mosquirix: Public Assessment Report （页面存档备份，存于互联网档案馆）

[ema-1] Mosquirix H-W-2300. European Medicines Agency (EMA). [4 March 2021]. （原始内容存档于2019-11-23）.

[2] RTS,S Malaria Vaccine: 2019 Partnership Award Honoree. YouTube. Global Health Technologies Coalition. [6 October 2021].

[npr-052022-3] 3.0 ^3.1 ^3.2 First malaria vaccine hits 1 million dose milestone — although it has its shortcomings. NPR. 13 May 2022 [2 January 2023]. （原始内容存档于2022-11-13）.

[unicef-082022-4] Millions more children to benefit from malaria vaccine as UNICEF secures supply. UNICEF. 16 August 2022 [2 January 2023]. （原始内容存档于2023-01-02）（英语）.

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