1-氨基-1-羧基茚滿-5-磷酸

APICA
臨床資料
ATC碼	未分配;
識別資訊
	IUPAC命名法 1-Amino-5-phosphonoindan-1-carboxylic acid; ;
CAS號	170847-18-4
PubChem CID	4694355;
ChemSpider	3881975 ;
ChEMBL	ChEMBL277961 ;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID201028297 ;
化學資訊
化學式	C10H12NO5P
摩爾質量	257.18 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES O=P(O)(O)c(c2)ccc1c2CCC1(N)C(O)=O;
	InChI InChI=1S/C10H12NO5P/c11-10(9(12)13)4-3-6-5-7(17(14,15)16)1-2-8(6)10/h1-2,5H,3-4,11H2,(H,12,13)(H2,14,15,16) ; Key:ZNQZXIHSJUDIKL-UHFFFAOYSA-N ;

1-氨基-1-羧基茚滿-5-磷酸（APICA）是一種有機化合物，化學式為C₁₀H₁₂NO₅P。它是一種藥物，可用於神經科學研究。它是II組代謝型穀氨酸受體（英語：Metabotropic_glutamate_receptor_2） (mGluR_2/3) 的選擇性拮抗劑。^[1]^[2]^[3]它可以3-溴苯甲醛和亞磷酸二乙酯（英語：Diethylphosphite）為原料經多步反應製得。^[2]

參考文獻

^ Ma D, Tian H, Sun H, Kozikowski AP, Pshenichkin S, Wroblewski JT. Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists.. Bioorganic & Medicinal Chemistry Letters. May 1997, 7 (9): 1195–1198. doi:10.1016/S0960-894X(97)00177-7 .
^ ^2.0 ^2.1 Ma D, Tian H, Zou G. Asymmetric Strecker-Type Reaction of alpha-Aryl Ketones. Synthesis of (S)-alphaM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the Antagonists of Metabotropic Glutamate Receptors. The Journal of Organic Chemistry. January 1999, 64 (1): 120–125. PMID 11674092. doi:10.1021/jo981297a.
^ Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW. Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. The Journal of Pharmacology and Experimental Therapeutics. January 2002, 300 (1): 162–71. PMID 11752112. doi:10.1124/jpet.300.1.162.