週期素依賴性激酶6

週期素依賴性激酶6
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	1BI7、1BI8、1BLX、1G3N、1JOW、1XO2、2EUF、2F2C、3NUP、3NUX、4AUA、4EZ5、4TTH
識別號
別名	CDK6；, MCPH12, PLSTIRE, cyclin-dependent kinase 6, cyclin dependent kinase 6
外部ID	OMIM：603368 MGI：1277162 HomoloGene：963 GeneCards：CDK6
相關疾病
	類風濕性關節炎、microcephaly 12, primary, autosomal recessive
為以下藥物的標靶
	帕布昔利布、trilaciclib、帕布昔利布、截癌寧、at-7519、AZD5438、瑞博西利
基因位置（人類）
染色體	7號染色體
終止	92,836,573 bp
基因位置（小鼠）
染色體	小鼠5號染色體
終止	3,581,008 bp
RNA表達模式
	查閱更多表達數據
基因本體
分子功能	• 轉移酶活性; • 蛋白激酶活性; • 核苷酸結合; • 細胞週期蛋白依賴性蛋白絲氨酸/蘇氨酸激酶活性; • 激酶活性; • 蛋白質絲氨酸/蘇氨酸激酶活性; • 血漿蛋白結合; • ATP結合; • 細胞週期蛋白結合; • FBXO family protein binding;
細胞組分	• 細胞質; • 中心體; • cell projection; • 細胞週期蛋白依賴性蛋白激酶全酶複合物; • ruffle; • 微管組織中心; • 細胞骨架; • 細胞核; • 細胞質基質; • 核質; • cyclin D2-CDK6 complex;
生物學過程	• 細胞分化; • lateral ventricle development; • 磷酸化; • positive regulation of cell-matrix adhesion; • positive regulation of fibroblast proliferation; • dentate gyrus development; • regulation of erythrocyte differentiation; • astrocyte development; • negative regulation of cell differentiation; • response to virus; • negative regulation of cell cycle; • negative regulation of osteoblast differentiation; • generation of neurons; • 細胞分裂; • regulation of cell motility; • protein phosphorylation; • negative regulation of epithelial cell proliferation; • 基因調節; • 細胞週期; • type B pancreatic cell development; • negative regulation of myeloid cell differentiation; • negative regulation of cellular senescence; • gliogenesis; • negative regulation of cell population proliferation; • negative regulation of monocyte differentiation; • 信號轉導; • regulation of G2/M transition of mitotic cell cycle; • regulation of cell population proliferation; • cell dedifferentiation; • G1/S transition of mitotic cell cycle; • negative regulation of transcription by RNA polymerase II; • hematopoietic progenitor cell differentiation; • Notch信號通路; • positive regulation of gene expression; • 造血作用; • T cell differentiation in thymus; • hematopoietic stem cell differentiation; • regulation of hematopoietic stem cell differentiation; • negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
直系同源
	1021
	12571
	ENSG00000105810
	ENSMUSG00000040274
	Q00534
	Q64261
	NM_001145306; NM_001259
	NM_009873
	NP_001138778; NP_001250
	NP_034003
	維基數據
檢視/編輯人類	檢視/編輯小鼠

週期素依賴性激酶6（英語：Cyclin-dependent kinase 6，CDK6）是一種由基因CDK6編碼的激酶，由週期素活化。具體來說，CDK6受週期素D活化，受CDK抑制蛋白抑制。

CDK6屬於週期素依賴性激酶（CDK）家族，其中包括週期素依賴性激酶4（CDK4）。

參考文獻

^ 與周期蛋白依赖性激酶6相關的疾病；在維基數據上查看/編輯參考.
^ 對Cyclin dependent kinase 6起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000105810 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000040274 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

擴展閱讀

外部連結

醫學主題詞表（MeSH）：Cyclin-Dependent+Kinase+6

這是一篇與生物化學相關的小作品。您可以透過編輯或修訂擴充其內容。

[1] 與周期蛋白依赖性激酶6相關的疾病；在維基數據上查看/編輯參考.

[2] 對Cyclin dependent kinase 6起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] 3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000105810 - Ensembl, May 2017

[refGRCm38Ensembl-4] 4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000040274 - Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

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