入地蜈蚣素K

入地蜈蚣素K
英文名	Ugonin K
識別
CAS號	651304-98-2
SMILES	OC1=C2C(OC(=CC2=O)C3=CC(O)=C(O)C=C3)=CC(OC)=C1C[C@@H]4C(C)(C)CCCC4=C;
性質
化學式	C26H28O6
摩爾質量	436.5 g·mol−1
外觀	黃色固體
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

入地蜈蚣素K是一種有機化合物，化學名為2-(3,4-二羥基苯基)-6[(1R)-2,2-二甲基-6-亚甲基环己基]甲基5-羥基-7-甲氧基-4H-1-苯並吡喃-4-酮，化學式為C₂₆H₂₈O₆。它是從七指蕨分離出的黃酮類化合物之一。^[1]它具有中等程度的抗糖尿病活性（IC₅₀=138.21±0.263 ppm）；^[2]它也對RAW264.7（捷克語：Buněčná linie RAW 264.7）細胞中RANKL誘導的破骨細胞分化表現出抑制活性（IC₅₀=1.8±0.2 μM）。^[3]

參考文獻

^ ^1.0 ^1.1 Yu-Ling Huang, Pei-Yu Yeh, Chien-Chang Shen, Chien-Chih Chen. Antioxidant flavonoids from the rhizomes of Helminthostachys zeylanica. Phytochemistry, 2003. 64 (7). 1277-1283. doi:10.1016/j.phytochem.2003.09.009.
^ Fania El Ridhasya, Novia Rahim, Muhammad Almurdani, Rudi Hendra, and Hilwan Yuda Teruna. Antidiabetic Constituents from Helminthostachys zeylanica (L) Hook (Ophioglossaceae). Pharmacognosy Journal, 2020, 12, 2, 223-226. doi:10.5530/pj.2020.12.33.
^ Yu-Ling Huang; et al. Anti-inflammatory and Antiosteoporosis Flavonoids from the Rhizomes of Helminthostachys zeylanica. J. Nat. Prod. 2017, 80, 2, 246–253. doi:10.1021/acs.jnatprod.5b01164.

[Huang-1] 1.0 ^1.1 Yu-Ling Huang, Pei-Yu Yeh, Chien-Chang Shen, Chien-Chih Chen. Antioxidant flavonoids from the rhizomes of Helminthostachys zeylanica. Phytochemistry, 2003. 64 (7). 1277-1283. doi:10.1016/j.phytochem.2003.09.009.

[2] Fania El Ridhasya, Novia Rahim, Muhammad Almurdani, Rudi Hendra, and Hilwan Yuda Teruna. Antidiabetic Constituents from Helminthostachys zeylanica (L) Hook (Ophioglossaceae). Pharmacognosy Journal, 2020, 12, 2, 223-226. doi:10.5530/pj.2020.12.33.

[3] Yu-Ling Huang; et al. Anti-inflammatory and Antiosteoporosis Flavonoids from the Rhizomes of Helminthostachys zeylanica. J. Nat. Prod. 2017, 80, 2, 246–253. doi:10.1021/acs.jnatprod.5b01164.

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