Trk受體
Trk受體（英語：Trk receptors）是一個可調節哺乳動物神經系統突觸的強度與可塑性的受體酪氨酸激酶家族[1]。Trk受體的激活通過多種信號通路影響神經元的存活和分化，同時也顯著影響神經元的功能。縮寫 Trk 或 trk，是 tropomyosin receptor kinase 或 tyrosine receptor kinase 的意思[2]。
Trk受體的共同配體是神經營養因子，一個在神經系統中其關鍵作用的生長因子家族[3]。它們互相之間的結合是高度特異性的。每種神經營養因子都有對應的不同的親和力的Trk受體。神經營養因子的結合造成的Trk受體的激活引起的信號通路 最終可導致細胞存活以及其它功能調控。
參考文獻
[編輯]- ^ Huang EJ, Reichardt LF. Trk receptors: roles in neuronal signal transduction. Annu. Rev. Biochem. 2003, 72: 609–642. PMID 12676795. doi:10.1146/annurev.biochem.72.121801.161629.
- ^ Malenka RC, Nestler EJ, Hyman SE. Chapter 8: Atypical neurotransmitters. Sydor A, Brown RY (編). Molecular Neuropharmacology: A Foundation for Clinical Neuroscience 2nd. New York: McGraw-Hill Medical. 2009. ISBN 9780071481274.
Another common feature of neurotrophins is that they produce their physiologic effects by means of the tropomyosin receptor kinase (Trk) receptor family (also known as the tyrosine receptor kinase family). ...
Trk receptors
All neurotrophins bind to a class of highly homologous receptor tyrosine kinases known as Trk receptors, of which three types are known: TrkA, TrkB, and TrkC. These transmembrane receptors are glycoproteins whose molecular masses range from 140 to 145 kDa. Each type of Trk receptor tends to bind specific neurotrophins: TrkA is the receptor for NGF, TrkB the receptor for BDNF and NT-4, and TrkC the receptor for NT-3.However, some overlap in the specificity of these receptors has been noted. - ^ Segal, Rosalind A. Selectivity in Neurotrophin Signalling: Theme and Variations. Annual Review of Neuroscience. 2003, 26: 299–330 [2013-11-11]. PMID 12598680. doi:10.1146/annurev.neuro.26.041002.131421. （原始內容存檔於2019-11-28）.