SCH-50911
外觀
SCH-50911 | |
---|---|
IUPAC名 2-[(2S)-5,5-Dimethylmorpholin-2-yl]acetic acid | |
識別 | |
CAS號 | 160415-07-6 |
PubChem | 5311429 |
ChemSpider | 4470917 |
SMILES |
|
InChI |
|
InChIKey | SEYCKMQSPUVYEF-LURJTMIEBV |
MeSH | SCH-50911 |
IUPHAR配體 | 1075 |
性質 | |
化學式 | C8H15NO3 |
摩爾質量 | 173.21 g·mol⁻¹ |
熔點 | 154.5-157 °C(428-430 K)(鹽酸鹽) |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
SCH-50911,分子式C8H15NO3,是一種γ-氨基丁酸β受體(GABAB)選擇性拮抗劑[1],用於治療酒精戒斷症候群中的震顫性譫妄而開發[2]。
參考文獻
[編輯]- ^ Blythin DJ, Kuo SC, Shue HJ, McPhail AT, Chapman RW, Kreutner W, et al. Substituted morpholine-2S-acetic acid derivatives: Sch 50911 and related compounds as novel GABAB antagonists.. Bioorganic & Medicinal Chemistry Letters. July 1996, 6 (13): 1529–34. doi:10.1016/S0960-894X(96)00267-3.
- ^ Quang LS, Colombo G, Lobina C, Maccioni P, Orru A, Gessa GL, et al. Evaluation for the withdrawal syndrome from gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (1,4-BD) in different rat lines. Annals of the New York Academy of Sciences. August 2006, 1074: 545–58. PMID 17105952. doi:10.1196/annals.1369.055.