頂胺A

頂胺A
別名	N6-[2-(1H-咪唑-5-基)乙基]-9H-嘌呤-2,6-二胺
識別
CAS號	94602-18-3
SMILES	N1=CNC(=C1)CCNC2=NC(=NC=3N=CNC32)N;
InChI	InChI=1S/C10H12N8/c11-10-17-8(7-9(18-10)16-5-15-7)13-2-1-6-3-12-4-14-6/h3-5H,1-2H2,(H,12,14)(H4,11,13,15,16,17,18);
InChIKey	CPFOTNMPWHCKHD-UHFFFAOYSA-N
性質
化學式	C10H12N8
摩爾質量	244.26 g·mol−1
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

頂胺A（Acroamine A）是一種有機化合物，化學式為C₁₀H₁₂N₈，它是組胺的嘌呤衍生物。^[1]它最初於1961年被合成，在2024年於澳洲頂群海葵（宿務語：Acrozoanthus australiae）（Acrozoanthus australiae）物種中發現並分離，而因此得名。^[2]它可以和碘甲烷反應，得到甲基化產物，或和N-溴代丁二酰亞胺反應，得到溴代產物。^[2]

參考文獻

^ Ballweg, Hubert. Purinderivate des Histamins. Justus Liebigs Annalen der Chemie, 1961. 649: 114-124. doi:10.1002/jlac.19616490114. ISSN 0075-4617. CODEN JLACBF
^ ^2.0 ^2.1 Senadeera, Sarath P. D.; Wang, Dongdong ; Wilson, Brice A. P. ; Smith, Emily A.; Wamiru, Antony; Martinez Fiesco, Juliana A.; Du, Lin ; Zhang, Ping; OKeefe, Barry R.; Beutler, John A. Acroamine A, a 2-Amino Adenine Alkaloid from the Marine Soft Coral Acrozoanthus australiae and Its Semisynthetic Derivatives That Inhibit cAMP-Dependent Protein Kinase A Catalytic Subunit Alpha. J. Nat. Prod. 2024, 87, 8, 2014–2020. doi:10.1021/acs.jnatprod.4c00477. ISSN 0163-3864.

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[1] Ballweg, Hubert. Purinderivate des Histamins. Justus Liebigs Annalen der Chemie, 1961. 649: 114-124. doi:10.1002/jlac.19616490114. ISSN 0075-4617. CODEN JLACBF

[Acroamine-2] 2.0 ^2.1 Senadeera, Sarath P. D.; Wang, Dongdong ; Wilson, Brice A. P. ; Smith, Emily A.; Wamiru, Antony; Martinez Fiesco, Juliana A.; Du, Lin ; Zhang, Ping; OKeefe, Barry R.; Beutler, John A. Acroamine A, a 2-Amino Adenine Alkaloid from the Marine Soft Coral Acrozoanthus australiae and Its Semisynthetic Derivatives That Inhibit cAMP-Dependent Protein Kinase A Catalytic Subunit Alpha. J. Nat. Prod. 2024, 87, 8, 2014–2020. doi:10.1021/acs.jnatprod.4c00477. ISSN 0163-3864.

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