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莽草酸脱氢酶

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维基百科,自由的百科全书
莽草酸脱氢酶
莽草酸脱氢酶结构
识别码
EC编号 1.1.1.25
CAS号 9026-87-3
数据库
IntEnz IntEnz浏览
BRENDA英语BRENDA BRENDA入口
ExPASy英语ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc英语MetaCyc 代谢路径
PRIAM英语PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum
基因本体 AmiGO / EGO

莽草酸脱氢酶(英语:shikimate dehydrogenaseEC 1.1.1.25页面存档备份,存于互联网档案馆))是一种以NADP+受体、作用于供体CH-OH基团上的氧化还原酶。这种催化以下酶促反应

莽草酸 + NADP+ 3-脱氢莽草酸 + NADH + H+

上述反应中的NADP+不能以NAD+替代[1]。莽草酸脱氢酶主要参与苯丙氨酸、酪氨酸色氨酸生物合成过程——莽草酸途径。在较高等的生物细胞中,这种酶与3-脱氢奎尼酸脱水酶一同构成一种多酶复合物[2]

功能

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Shikimate dehydrogenase is an enzyme that catalyzes one step of the shikimate pathway. This pathway is found in bacteria, plants, fungi, algae, and parasites and is responsible for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine, and tryptophan) from the metabolism of carbohydrates. In contrast, animals and humans lack this pathway hence products of this biosynthetic route are essential amino acids that must be obtained through an animal's diet.

There are seven enzymes that play a role in this pathway. Shikimate dehydrogenase (also known as 3-dehydroshikimate dehydrogenase) is the fourth step of the seven step process. This step converts 3-dehydroshikimate to shikimate as well as reduces NADP+ to NADPH.

异名

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由于莽草酸脱氢酶催化一个可逆的氧化还原反应,且对于莽草酸碳原子编号顺序不同,所以除了它的系统名:shikimate:NADP+ 3-oxidoreductase 莽草酸:NADP+ 3-氧化还原酶之外,还存在多个异名:

  • dehydroshikimic reductase 脱氢莽草酸还原酶
  • shikimate oxidoreductase 莽草酸氧化还原酶
  • shikimate:NADP+ oxidoreductase 莽草酸:NADP+ 氧化还原酶
  • 5-dehydroshikimate reductase 5-脱氢莽草酸还原酶
  • shikimate 5-dehydrogenase 莽草酸 5-脱氢酶
  • 5-dehydroshikimic reductase 5-脱氢莽草酸还原酶
  • DHS reductase DHS还原酶
  • shikimate:NADP+ 5-oxidoreductase 莽草酸:NADP+ 5-氧化还原酶
  • AroE。

参考文献

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  1. ^ Yaniv H, Gilvarg C. Aromatic biosynthesis. XIV. 5-Dehydroshikimic reductase. J. Biol. Chem. 1955, 213 (2): 787–95. PMID 14367339. 
  2. ^ Chaudhuri S, Coggins JR. The purification of shikimate dehydrogenase from Escherichia coli. Biochem. J. 1985, 226 (1): 217–23. PMC 1144695可免费查阅. PMID 3883995.