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庚酸雄甾醇酮

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庚酸雄甾醇酮
临床资料
商品名英语Drug nomenclatureAnaboleen Depot
其他名称Stanolone enanthate; Dihydrotestosterone enanthate; DHT enanthate; Dihydrotestosterone heptanoate; DHTH; 5α-Androstan-17β-ol-3-one 17β-heptanoate
给药途径Intramuscular injection
药物类别英语Drug classAndrogen; Anabolic steroid; Androgen ester
识别信息
  • [(5S,8R,9S,10S,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl] heptanoate
CAS号33776-88-4
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C26H42O3
摩尔质量402.62 g·mol−1
3D模型(JSmol英语JSmol
  • CCCCCCC(=O)O[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CCC(=O)C4)C)C
  • InChI=1S/C26H42O3/c1-4-5-6-7-8-24(28)29-23-12-11-21-20-10-9-18-17-19(27)13-15-25(18,2)22(20)14-16-26(21,23)3/h18,20-23H,4-17H2,1-3H3/t18-,20-,21-,22-,23-,25-,26-/m0/s1
  • Key:DDYHAKNCTGGYOK-LVYWIKMTSA-N

庚酸雄甾醇酮(英语:Androstanolone enanthate),也称为庚酸雄诺龙庚酸二氢睾酮,是一种合成的雄激素合成代谢类固醇二氢睾酮酯。[1][2]它用作注射剂,并作为雄甾醇酮二氢睾酮)的前体药物。该药物已被研究并发现可有效治疗男孩和成年男性的男性乳房发育症[3][4][5]已对庚酸雄甾醇酮的药理学进行了研究。[6][7]

参见

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参考资料

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  1. ^ J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 640–. ISBN 978-1-4757-2085-3. 
  2. ^ I.K. Morton; Judith M. Hall. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 6 December 2012: 261–. ISBN 978-94-011-4439-1. 
  3. ^ Swerdloff, Ronald S.; Wang, Christina. Dihydrotestosterone: A rationale for its use as a non-aromatizable androgen replacement therapeutic agent. Baillière's Clinical Endocrinology and Metabolism. 1998, 12 (3): 501–506. ISSN 0950-351X. PMID 10332569. doi:10.1016/S0950-351X(98)80267-X. 
  4. ^ Eberle AJ, Sparrow JT, Keenan BS. Treatment of persistent pubertal gynecomastia with dihydrotestosterone heptanoate. J. Pediatr. 1986, 109 (1): 144–9. PMID 3088241. doi:10.1016/s0022-3476(86)80596-0. 
  5. ^ Swerdloff, Ronald S.; Dudley, Robert E.; Page, Stephanie T.; Wang, Christina; Salameh, Wael A. Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels. Endocrine Reviews. 2017, 38 (3): 220–254. ISSN 0163-769X. PMC 6459338可免费查阅. PMID 28472278. doi:10.1210/er.2016-1067可免费查阅. 
  6. ^ Keenan, Bruce S.; Eberle, Andrea J.; Sparrow, James T.; Greger, Nancy G.; Panko, Walter B. Dihydrotestosterone Heptanoate: Synthesis, Pharmacokinetics, and Effects on Hypothalamic-Pituitary-Testicular Function. The Journal of Clinical Endocrinology & Metabolism. 1987, 64 (3): 557–562. ISSN 0021-972X. PMID 3546348. doi:10.1210/jcem-64-3-557. 
  7. ^ Coutts SB, Kicman AT, Hurst DT, Cowan DA. Intramuscular administration of 5 alpha-dihydrotestosterone heptanoate: changes in urinary hormone profile. Clin. Chem. November 1997, 43 (11): 2091–8. PMID 9365393. doi:10.1093/clinchem/43.11.2091可免费查阅.