SIRT1

SIRT1
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4I5I、4IF6、4IG9、4KXQ、4ZZH、4ZZI、4ZZJ、5BTR
识别号
别名	SIRT1；, SIR2L1, SIR2, hSIR2, SIR2alpha, Sirtuin 1
外部ID	OMIM：604479 MGI：2135607 HomoloGene：56556 GeneCards：SIRT1
为以下药物的标靶
	SRT-1720
基因位置（人类）
染色体	10号染色体
终止	67,918,390 bp
基因位置（小鼠）
染色体	小鼠10号染色体
终止	63,217,483 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• transcription corepressor activity; • protein domain specific binding; • core promoter sequence-specific DNA binding; • protein C-terminus binding; • keratin filament binding; • 转录因子结合; • 金属离子结合; • HLH domain binding; • 酶结合; • protein deacetylase activity; • histone binding; • 血浆蛋白结合; • NAD-dependent histone deacetylase activity; • NAD-dependent protein deacetylase activity; • histone deacetylase activity; • p53 binding; • mitogen-activated protein kinase binding; • deacetylase activity; • bHLH transcription factor binding; • NAD+ binding; • 相同蛋白质结合; • NAD+ ADP-ribosyltransferase activity; • 水解酶活性; • NAD-dependent histone deacetylase activity (H3-K9 specific); • DNA-binding transcription activator activity, RNA polymerase II-specific;
细胞组分	• 细胞质; • nuclear envelope; • rDNA heterochromatin; • chromatin silencing complex; • 线粒体; • 细胞核; • ESC/E(Z) complex; • 核仁; • 染色质; • 核质; • PML body; • 内膜; • 细胞质基质;
生物学过程	• cellular triglyceride homeostasis; • positive regulation of MHC class II biosynthetic process; • DNA synthesis involved in DNA repair; • positive regulation of protein phosphorylation; • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; • rhythmic process; • single strand break repair; • muscle organ development; • histone H3-K9 deacetylation; • negative regulation of cellular response to testosterone stimulus; • regulation of peroxisome proliferator activated receptor signaling pathway; • cellular response to DNA damage stimulus; • regulation of bile acid biosynthetic process; • 脱氧核糖核酸复制; • negative regulation of TOR signaling; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • regulation of glucose metabolic process; • rDNA heterochromatin assembly; • negative regulation of DNA damage response, signal transduction by p53 class mediator; • DNA methylation-dependent heterochromatin assembly; • 昼夜节律; • positive regulation of cellular senescence; • 精子发生; • intrinsic apoptotic signaling pathway in response to DNA damage; • cellular response to ionizing radiation; • negative regulation of helicase activity; • cholesterol homeostasis; • response to leptin; • cellular response to hypoxia; • triglyceride mobilization; • negative regulation of prostaglandin biosynthetic process; • proteasome-mediated ubiquitin-dependent protein catabolic process; • 细胞凋亡; • peptidyl-lysine deacetylation; • negative regulation of fat cell differentiation; • negative regulation of peptidyl-lysine acetylation; • regulation of transcription, DNA-templated; • positive regulation of adaptive immune response; • stress-induced premature senescence; • negative regulation of androgen receptor signaling pathway; • negative regulation of transforming growth factor beta receptor signaling pathway; • response to oxidative stress; • negative regulation of DNA-binding transcription factor activity; • negative regulation of gene expression; • transcription, DNA-templated; • negative regulation of cAMP-dependent protein kinase activity; • pyrimidine dimer repair by nucleotide-excision repair; • response to insulin; • histone H3-K9 modification; • positive regulation of macroautophagy; • positive regulation of cholesterol efflux; • protein ubiquitination; • negative regulation of cell growth; • positive regulation of macrophage apoptotic process; • rRNA processing; • regulation of brown fat cell differentiation; • negative regulation of phosphorylation; • viral process; • DNA修复; • negative regulation of neuron death; • positive regulation of histone H3-K9 methylation; • negative regulation of histone H3-K14 acetylation; • negative regulation of protein kinase B signaling; • 细胞分化; • ovulation from ovarian follicle; • regulation of protein serine/threonine kinase activity; • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • protein ADP-ribosylation; • leptin-mediated signaling pathway; • negative regulation of apoptotic process; • negative regulation of transcription by RNA polymerase II; • chromatin organization; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • circadian regulation of gene expression; • protein deacetylation; • fatty acid homeostasis; • protein destabilization; • regulation of mitotic cell cycle; • positive regulation of cAMP-dependent protein kinase activity; • white fat cell differentiation; • positive regulation of insulin receptor signaling pathway; • negative regulation of transcription, DNA-templated; • negative regulation of NF-kappaB transcription factor activity; • peptidyl-lysine acetylation; • response to hydrogen peroxide; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • negative regulation of histone H4-K16 acetylation; • positive regulation of endothelial cell proliferation; • regulation of smooth muscle cell apoptotic process; • behavioral response to starvation; • cellular glucose homeostasis; • cellular response to starvation; • cellular response to tumor necrosis factor; • positive regulation of DNA repair; • multicellular organism development; • regulation of cell population proliferation; • positive regulation of cell population proliferation; • regulation of endodeoxyribonuclease activity; • regulation of cellular response to heat; • positive regulation of phosphatidylinositol 3-kinase signaling; • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; • UV-damage excision repair; • histone deacetylation; • positive regulation of transcription by RNA polymerase II; • 血管新生; • macrophage cytokine production; • regulation of lipid storage; • positive regulation of adipose tissue development; • macrophage differentiation; • transcription by RNA polymerase II; • positive regulation of smooth muscle cell differentiation; • negative regulation of histone H3-K9 trimethylation; • positive regulation of apoptotic process; • cellular response to hydrogen peroxide; • histone H3 deacetylation; • negative regulation of protein acetylation; • regulation of apoptotic process; • cellular response to leukemia inhibitory factor; • positive regulation of angiogenesis; • transforming growth factor beta receptor signaling pathway; • positive regulation of blood vessel endothelial cell migration; • negative regulation of cellular senescence;
	Sources:Amigo / QuickGO
直系同源
	23411
	93759
	ENSG00000096717
	ENSMUSG00000020063
	Q96EB6
	Q923E4
	NM_001142498; NM_001314049; NM_012238
	NM_001159589; NM_001159590; NM_019812
	NP_001135970; NP_001300978; NP_036370
	NP_001153061; NP_062786
	维基数据
查看/编辑人类	查看/编辑小鼠

SIRT1（英语：Sirtuin 1），也被称为 NAD-依赖性去乙酰化酶Sirtuin-1（英语：NAD-dependent deacetylase sirtuin-1），是人类基因组中由SIRT1基因编码的蛋白。人的SIRT1基因位于10号染色体上。SIRT1的功能是去除蛋白质上的乙酰基团（去乙酰化）。SIRT1的去乙酰化功能在一些生物学过程中有发挥一定的作用^[6]^[7]^[8]。

参考文献

^ 對SIRT1起作用的藥物；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000096717 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020063 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Frye, R. A. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochemical and Biophysical Research Communications. 1999-06-24, 260 (1): 273–279 [2021-11-10]. ISSN 0006-291X. PMID 10381378. doi:10.1006/bbrc.1999.0897. （原始内容存档于2021-11-10）.
^ SIRT1 sirtuin 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. （原始内容存档于2021-11-10）.
^ Template:UCSC genome browser

外部链接

Corante weblog by Derek Lowe about sir2 and SIRT1 research.

这是一篇与生物化学相关的小作品。您可以通过编辑或修订扩充其内容。

[1] 對SIRT1起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000096717 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020063 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10381378-6] Frye, R. A. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochemical and Biophysical Research Communications. 1999-06-24, 260 (1): 273–279 [2021-11-10]. ISSN 0006-291X. PMID 10381378. doi:10.1006/bbrc.1999.0897. （原始内容存档于2021-11-10）.

[entrez-7] SIRT1 sirtuin 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. （原始内容存档于2021-11-10）.

[UCSC_SIRT1-8] Template:UCSC genome browser

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查论编水解酶类：碳-氮非肽（EC 3.5）
3.5.1：线性酰胺/ 酰胺水解酶	天冬酰胺酶谷氨酰胺酶脲酶生物素酶氨基酰化酶 ACY1 天冬氨酸酰酶 ACY3 神经酰胺酶天门冬酰胺氨基葡萄糖酶脂肪酰胺水解酶组蛋白脱乙酰酶 Sirtuin：1、2、3、5、6、7
3.5.2：环状酰胺/ 酰胺水解酶	丙二酰脲酶 β-内酰胺酶二氢乳清酸酶
3.5.3：线性脒/ 脲水解酶	精氨酸酶鲱精胺酶蛋白质-精氨酸脱亚氨酶
3.5.4：环状脒/ 氨基水解酶	鸟嘌呤脱氨酶腺苷脱氨酶 AMP脱氨酶肌苷单磷酸合酶 DCMP脱氨酶 GTP环水解酶I 胞苷脱氨酶激活诱导性胞苷脱氨酶
3.5.5：腈/ 氨基水解酶	腈水解酶
3.5.99：其他	核黄素酶硫胺酶II
EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 · 4.1/2/3/4/5/6 · 5.1/2/3/4/5/99 · 6.1-3（英语：Template:Ligases CO CS and CN）/4/5-6