PANC-1

PANC-1是人类胰腺癌细胞系^[1]，最初是分离一名56岁男性胰腺癌患者。PANC-1细胞可以远端转移，但细胞分化的能力差^[2]，需要52个小时才能增加一倍的种群。PANC-1细胞的模态染色体数为63，包括3个独特的标记染色体（英语：Marker chromosome）和1个小环状染色体，并且显示出慢迁移性类型的G6PD^[1]。目前已知PANC-1细胞具有上皮形态及会粘附在细胞培养瓶中。只要适当地提高细胞的温度，细胞就会在培养物中再度生长。PANC-1细胞有结块的趋势，而进行胰蛋白酶的处理则可以避免这种现象^[3]。PANC-1细胞已被用于研究角蛋白重组在癌细胞迁移过程中的作用，以及钙介导的肌动蛋白在响应生理变化时的重置^[2]。

参考资料[编辑]

^ ^1.0 ^1.1 Lieber, M; Mazzetta, J; Nelson-Rees, W; Kaplan, M; Todaro, G. Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas.. International journal of cancer. 1975-05-15, 15 (5): 741–7 [2020-01-12]. PMID 1140870. doi:10.1002/ijc.2910150505. （原始内容存档于2020-01-12）.
^ ^2.0 ^2.1 Deer, EL; González-Hernández, J; Coursen, JD; Shea, JE; Ngatia, J; Scaife, CL; Firpo, MA; Mulvihill, SJ. Phenotype and genotype of pancreatic cancer cell lines.. Pancreas. 2010-05, 39 (4): 425–35 [2020-01-12]. PMID 20418756. doi:10.1097/MPA.0b013e3181c15963. （原始内容存档于2020-01-12）.
^ Thompson Evonne. Cell Growth Protocol for PANC-1 cell line (PDF). Myers Laboratory. 2009-07-22 [2020-01-12]. （原始内容存档 (PDF)于2017-09-18）（英语）.

外部链接[编辑]

Cellosaurus entry for PANC-1（页面存档备份，存于互联网档案馆）

[a-1] 1.0 ^1.1 Lieber, M; Mazzetta, J; Nelson-Rees, W; Kaplan, M; Todaro, G. Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas.. International journal of cancer. 1975-05-15, 15 (5): 741–7 [2020-01-12]. PMID 1140870. doi:10.1002/ijc.2910150505. （原始内容存档于2020-01-12）.

[b-2] 2.0 ^2.1 Deer, EL; González-Hernández, J; Coursen, JD; Shea, JE; Ngatia, J; Scaife, CL; Firpo, MA; Mulvihill, SJ. Phenotype and genotype of pancreatic cancer cell lines.. Pancreas. 2010-05, 39 (4): 425–35 [2020-01-12]. PMID 20418756. doi:10.1097/MPA.0b013e3181c15963. （原始内容存档于2020-01-12）.

[3] Thompson Evonne. Cell Growth Protocol for PANC-1 cell line (PDF). Myers Laboratory. 2009-07-22 [2020-01-12]. （原始内容存档 (PDF)于2017-09-18）（英语）.

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