RBL-1

RBL-1（Rat Basophilic Leukemia cells^[1]）是大鼠嗜鹼性粒細胞性白血病（英语：Acute basophilic leukemia）細胞系。由於RBL-1細胞對免疫球蛋白E及其FCER1（英语：FCER1）受體的強烈反應，因此被用於研究過敏反應，並且因為它們在組織培養中具有更高的穩定性，因此它們被用於代替肥大細胞^[2]。同時，RBL細胞有助於對人類患者進行過敏性研究^[3]^[4]。黴漿菌感染極大地影響了生物測定中細胞介體的釋放。由於細菌會在RBL-1細胞的表面上生長，並且無法通過光學顯微鏡對其進行觀察，因此需要進行常規的支原體檢測。

參考資料[编辑]

^ Bingham, B.R.; Monk, P.N.; Helm, B.A. Defective Protein Phosphorylation and Ca2+ Mobilization Linowa SecretingVariant of the Rat Basophilic Leukemia Cell Line. The Journal of Biological Chemistry. 1994, 269 (30): 19300–19306.
^ Wang, Weimin; et al. Anti-allergic activity of emodin on IgE-mediated activation in RBL-2H3 cells (PDF). Pharmacological Reports. 2012, (64): 1216–1222 [2020-01-08]. ISSN 1734-1140. （原始内容存档 (PDF)于2017-07-05）.
^ Yoo, JM; Sok, DE; Kim, MR. Anti-allergic action of aged black garlic extract in RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.. Journal of medicinal food. 2014-01, 17 (1): 92–102 [2020-01-08]. PMID 24456359. doi:10.1089/jmf.2013.2927. ^{[永久失效連結]}
^ Falcone, FH; Alcocer, MJ; Okamoto-Uchida, Y; Nakamura, R. Use of humanized rat basophilic leukemia reporter cell lines as a diagnostic tool for detection of allergen-specific IgE in allergic patients: time for a reappraisal?. Current allergy and asthma reports. 2015-11, 15 (11): 67 [2020-01-08]. PMID 26452547. doi:10.1007/s11882-015-0568-3. ^{[永久失效連結]}

外部連結[编辑]

Cellosaurus entry for RBL-1（页面存档备份，存于互联网档案馆）

这是一篇與生物学相關的小作品。你可以通过编辑或修订扩充其内容。

[1] Bingham, B.R.; Monk, P.N.; Helm, B.A. Defective Protein Phosphorylation and Ca2+ Mobilization Linowa SecretingVariant of the Rat Basophilic Leukemia Cell Line. The Journal of Biological Chemistry. 1994, 269 (30): 19300–19306.

[2] Wang, Weimin; et al. Anti-allergic activity of emodin on IgE-mediated activation in RBL-2H3 cells (PDF). Pharmacological Reports. 2012, (64): 1216–1222 [2020-01-08]. ISSN 1734-1140. （原始内容存档 (PDF)于2017-07-05）.

[3] Yoo, JM; Sok, DE; Kim, MR. Anti-allergic action of aged black garlic extract in RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.. Journal of medicinal food. 2014-01, 17 (1): 92–102 [2020-01-08]. PMID 24456359. doi:10.1089/jmf.2013.2927. ^{[永久失效連結]}

[4] Falcone, FH; Alcocer, MJ; Okamoto-Uchida, Y; Nakamura, R. Use of humanized rat basophilic leukemia reporter cell lines as a diagnostic tool for detection of allergen-specific IgE in allergic patients: time for a reappraisal?. Current allergy and asthma reports. 2015-11, 15 (11): 67 [2020-01-08]. PMID 26452547. doi:10.1007/s11882-015-0568-3. ^{[永久失效連結]}

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