P1-185

P1-185
臨床資料
其他名稱	(3E)-3-({[(2S)-2-Amino-3-methylbutanoyl]oxy}imino)pregn-4-en-20-one
藥物類別	孕激素、神经甾体
识别信息
	IUPAC命名法 [(E)-[(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]amino] (2S)-2-amino-3-methylbutanoate; ;
CAS号	1185297-01-1
PubChem CID	44219330;
ChemSpider	25052147;
ChEMBL	ChEMBL565873;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID801148453 ;
化学信息
化学式	C26H40N2O3
摩尔质量	428.62 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CC(C)[C@@H](C(=O)O/N=C/1\CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CCC2=C1)CC[C@@H]4C(=O)C)C)C)N;
	InChI InChI=1S/C26H40N2O3/c1-15(2)23(27)24(30)31-28-18-10-12-25(4)17(14-18)6-7-19-21-9-8-20(16(3)29)26(21,5)13-11-22(19)25/h14-15,19-23H,6-13,27H2,1-5H3/b28-18+/t19-,20+,21-,22-,23-,25-,26+/m0/s; Key:JFIPYWOCXPCAFX-NPRMJFGVSA-N;

P1-185（化学名：孕甾-4-烯-3,20-二酮 3-O-(L-缬氨酰)-E-肟，英語：pregn-4-ene-3,20-dione 3-O-(L-valine)-E-oxime）是一种含氮有机化合物，化学式C
26H
40N
2O
3，属于人工合成的孕激素和神经甾体^[1]^[2]。

参考文献

^ MacNevin CJ, Atif F, Sayeed I, Stein DG, Liotta DC. Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury. J. Med. Chem. 2009, 52 (19): 6012–23. PMID 19791804. doi:10.1021/jm900712n.
^ Guthrie DB, Stein DG, Liotta DC, Lockwood MA, Sayeed I, Atif F, Arrendale RF, Reddy GP, Evers TJ, Marengo JR, Howard RB, Culver DG, Natchus MG. Water-soluble progesterone analogues are effective, injectable treatments in animal models of traumatic brain injury. ACS Med Chem Lett. 2012, 3 (5): 362–6. PMC 4025794 . PMID 24900479. doi:10.1021/ml200303r.