JWH-370

JWH-370
法律規範狀態
法律規範	加：Schedule II; 英：Class B;
识别信息
	IUPAC命名法 [5-(2-methylphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone; ;
CAS号	914458-22-3
PubChem CID	44418312;
ChemSpider	23277889 ;
UNII	HJZ9JN4HNM;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID701016340 ;
化学信息
化学式	C27H27NO
摩尔质量	381.52 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CCCCCN1C=C(C=C1C2=CC=CC=C2C)C(=O)C3=CC=CC4=CC=CC=C43;
	InChI InChI=1S/C27H27NO/c1-3-4-9-17-28-19-22(18-26(28)23-14-7-5-11-20(23)2)27(29)25-16-10-13-21-12-6-8-15-24(21)25/h5-8,10-16,18-19H,3-4,9,17H2,1-2H3 ; Key:HZMLAMXVETUEJZ-UHFFFAOYSA-N ;

JWH-370，化学名N-正戊基-5-邻甲苯基-3-(1-萘甲酰基)吡咯，分子式C
27H
27NO，属于萘甲酰基吡咯类JWH系列大麻素，是大麻素受体CB₁和CB₂的激动剂^[1]。它可通过LC-MS法检测，其前体离子的m/z为382，产物离子的m/z为127。^[2]

参考文献

^ Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR. 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorganic & Medicinal Chemistry Letters. October 2006, 16 (20): 5432–5. PMID 16889960. doi:10.1016/j.bmcl.2006.07.051.
^ Arianna Giorgetti; et al. Development and validation of a rapid LC-MS/MS method for the detection of 182 novel psychoactive substances in whole blood. Drug Testing and Analysis (2022), 14 (2), 202-223. doi:10.1002/dta.3170.