BNN-20

BNN-20
臨床資料
其他名稱	BNN20; 17β-Spiro-(androst-5-en-17,2'-oxiran)-3β-ol
识别信息
	IUPAC命名法 (3S,8R,9S,10R,13S,14S,17S)-10,13-Dimethylspiro[1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,2'-oxirane]-3-ol; ;
CAS号	847-75-6
PubChem CID	44542342;
ChemSpider	24661247;
UNII	5WM22TG224;
ChEMBL	ChEMBL1076355;
化学信息
化学式	C20H30O2
摩尔质量	302.46 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]45CO5)C)O;
	InChI InChI=1S/C20H30O2/c1-18-8-5-14(21)11-13(18)3-4-15-16(18)6-9-19(2)17(15)7-10-20(19)12-22-20/h3,14-17,21H,4-12H2,1-2H3/t14-,15+,16-,17-,18-,19-,20+/m0/s1; Key:LKDLANDMNIFZOI-IJMQKCTASA-N;

BNN-20（化学名：17β-螺-(雄甾-5-烯-17,2'-环氧)-3β-醇，英語：17β-spiro-(androst-5-en-17,2'-oxiran)-3β-ol）是一种有机化合物，化学式C
20H
30O
2，是一种人工合成的神经甾体。^[1]^[2]

参考文献

^ Calogeropoulou T, Avlonitis N, Minas V, Alexi X, Pantzou A, Charalampopoulos I, Zervou M, Vergou V, Katsanou ES, Lazaridis I, Alexis MN, Gravanis A. Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity. J. Med. Chem. 2009, 52 (21): 6569–87. PMID 19845386. doi:10.1021/jm900468p.
^ Botsakis K, Mourtzi T, Panagiotakopoulou V, Vreka M, Stathopoulos GT, Pediaditakis I, Charalampopoulos I, Gravanis A, Delis F, Antoniou K, Zisimopoulos D, Georgiou CD, Panagopoulos NT, Matsokis N, Angelatou F. BNN-20, a synthetic microneurotrophin, strongly protects dopaminergic neurons in the "weaver" mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor. Neuropharmacology. 2017, 121: 140–157. PMID 28461162. S2CID 5071762. doi:10.1016/j.neuropharm.2017.04.043.