18-甲氨基冠狗牙花定碱

18-甲氨基冠狗牙花定碱
识别信息
CAS号	1807784-35-5 [EPA]
PubChem CID	71308131;
ChemSpider	24721797 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID301046165 ;
化学信息
化学式	C22H29N3O2
摩尔质量	367.49 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES c4cccc1c4[nH]c3c1CCN2CC(C5)CC3(C(=O)OC)C2C5CCNC;
	InChI InChI=1S/C22H29N3O2/c1-23-9-7-15-11-14-12-22(21(26)27-2)19-17(8-10-25(13-14)20(15)22)16-5-3-4-6-18(16)24-19/h3-6,14-15,20,23-24H,7-13H2,1-2H3/t14-,15+,20+,22-/m1/s1 ; Key:YKMOJVPLIUXEIP-SVBQBFEESA-N ;

18-甲氨基冠狗牙花定碱（英語：18-Methylaminocoronaridine，缩写18-MAC）是一种有机化合物，分子式C₂₂H₂₉N₃O₂，属于伊波加因的衍生物，由佛蒙特大學的药理学家开发为药物。^[1]^[2]

参考文献

^ Kuehne ME, He L, Jokiel PA, Pace CJ, Fleck MW, Maisonneuve IM, et al. Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. Journal of Medicinal Chemistry. June 2003, 46 (13): 2716–30. PMID 12801235. doi:10.1021/jm020562o.
^ Pace CJ, Glick SD, Maisonneuve IM, He LW, Jokiel PA, Kuehne ME, Fleck MW. Novel iboga alkaloid congeners block nicotinic receptors and reduce drug self-administration. European Journal of Pharmacology. May 2004, 492 (2–3): 159–67. PMID 15178360. doi:10.1016/j.ejphar.2004.03.062.