特立妥單抗
| 单克隆抗体 | |
|---|---|
| 种类 | 双特异性T细胞接合器 |
| 目標 | BCMA, CD3 |
| 臨床資料 | |
| 其他名稱 | JNJ-64007957, teclistamab-cqyv |
| 核准狀況 | |
| 懷孕分級 | |
| 给药途径 | 皮下注射 |
| 藥物類別 | 化学疗法 |
| ATC碼 | |
| 法律規範狀態 | |
| 法律規範 |
|
| 识别信息 | |
| CAS号 | 2119595-80-9 |
| DrugBank | |
| UNII | |
| KEGG | |
| 化学信息 | |
| 化学式 | C6383H9847N1695O2003S40 |
| 摩尔质量 | 143,662.25 g·mol−1 |
特立妥單抗（INN：Teclistamab）用于治疗多發性骨髓瘤[8]。当其他治疗无效时，會采用的後線治療[8]。透过皮下注射给药[9]。
常见副作用包括发烧、细胞因子释放综合征、肌肉疼痛、疲倦、上呼吸道感染、肺炎、腹瀉、白细胞减少症、贫血和血小板減少症[9]。其他副作用包括可能肝脏问题、感染和过敏反应[9]。孕期使用可能對婴儿有害[9]。它是一种单克隆抗体，可同时接上T细胞上的CD3受体和骨髓瘤细胞上的B细胞成熟抗原[8]。
特立妥單抗于 2022 年在欧洲和美国取得医疗使用許可[8] [9]。但到 2022 年止，它仍未取得英国的醫療使用許可[10]。
参考文獻
[编辑]- ^ Tecvayli. Therapeutic Goods Administration (TGA). 28 June 2023 [10 September 2023]. （原始内容存档于19 November 2023）.
- ^ Tecvayli (Janssen-Cilag Pty Ltd). Therapeutic Goods Administration (TGA). 28 July 2023 [10 September 2023]. （原始内容存档于19 November 2023）.
- ^ Details for: Tecvayli. Health Canada. 20 October 2023 [3 March 2024]. （原始内容存档于3 March 2024）.
- ^ Notice: Multiple additions to the Prescription Drug List (PDL) [2023-10-26]. Health Canada. 26 October 2023 [3 January 2024]. （原始内容存档于3 January 2024）.
- ^ Tecvayli- teclistamab injection. DailyMed. 31 October 2022 [18 November 2022]. （原始内容存档于18 November 2022）.
- ^ Drug Approval Package: Tecvayli. U.S. Food and Drug Administration (FDA). 23 November 2022 [4 December 2022]. （原始内容存档于4 December 2022）.
- ^ Tecvayli EPAR. European Medicines Agency. 18 July 2022 [14 October 2022]. （原始内容存档于10 December 2022）. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ^ 8.0 8.1 8.2 8.3 Tecvayli EPAR. European Medicines Agency. 18 July 2022 [14 October 2022]. （原始内容存档于10 December 2022）. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ^ 9.0 9.1 9.2 9.3 9.4 Tecvayli- teclistamab injection. DailyMed. 31 October 2022 [18 November 2022]. （原始内容存档于18 November 2022）.
- ^ Teclistamab. SPS - Specialist Pharmacy Service. 24 September 2021 [16 December 2022]. （原始内容存档于2 December 2021）.
