The Plaza Murillo is the central plaza of the city of La Paz and the open space most connected to the political life of Bolivia. Prominent buildings on the plaza include the Presidential Palace, National Congress of Bolivia, and the Cathedral of La Paz. It is located in the old town, or Casco Viejo, of the city and is surrounded by Socabaya Street to the west, Ayacucho Street to the east, Comercio Street to the south, and a continuation of Ingavi and Ballivan Streets to the north.

The Plaza was originally named the Plaza Mayor (Greatest/Main Plaza) after its construction. It was later known during the colonial period as the Plaza de Armas. Following independence, it was renamed the July 16 Plaza (Plaza 16 de Julio) in honor of the founding document of independence signed in 1809 in La Paz. Finally, it was renamed Plaza Murillo on February 3, 1902, in honor of Pedro Murillo, one of the signers of that document, who was captured and hung by Spanish troops in January 1810.

The plaza was designed in 1558 as part of the rectilinear grid of La Paz by Juan Gutierrez Paniagua, who was appointed by Corregidor Ignacio de Aranda, to order the city on the north bank of the Choqueyapu River. This region of the city was opposite the existing Spanish settlement, which had numbered about 200 Spaniards with some 5,000 tributary indigenous residents. The Plaza Mayor quickly supplanted the previous central square of the Spaniards, which is now called Plaza Alonso de Mendoza. Colonial buildings that were built surrounding the plaza include the Cabildo (or city government building, including a jail), a building of the Society of Jesus, the Cathedral, the Royal Treasury (Cajas Reales), and the Bishop's Residence (Casa Obispal).