胰岛素样生长因子1

胰岛素样生长因子1
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1B9G、1GZR、1GZY、1GZZ、1H02、1H59、1IMX、1PMX、1TGR、1WQJ、2DSR、2GF1、3GF1、3LRI、1BQT、4XSS
識別號
别名	IGF1；, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
外部ID	OMIM：147440 MGI：96432 HomoloGene：515 GeneCards：IGF1
相關疾病
	growth delay due to insulin-like growth factor type 1 deficiency
基因位置（人类）
染色体	12號染色體
终止	102,481,744 bp
基因位置（小鼠）
染色体	小鼠10号染色体
终止	87,772,904 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本體
分子功能	• hormone activity; • insulin receptor binding; • 生長因子活性; • integrin binding; • 血浆蛋白结合; • insulin-like growth factor receptor binding;
細胞組分	• 細胞外區域; • exocytic vesicle; • insulin-like growth factor binding protein complex; • platelet alpha granule lumen; • insulin-like growth factor ternary complex; • alphav-beta3 integrin-IGF-1-IGF1R complex; • 细胞膜; • 細胞外空間;
生物學過程	• positive regulation of transcription regulatory region DNA binding; • 骨骼系统的发生; • positive regulation of glucose import; • muscle organ development; • positive regulation of Ras protein signal transduction; • response to heat; • positive regulation of cardiac muscle hypertrophy; • positive regulation of smooth muscle cell migration; • 脫氧核糖核酸複製; • positive regulation of insulin-like growth factor receptor signaling pathway; • phosphatidylinositol 3-kinase signaling; • positive regulation of DNA binding; • Ras protein signal transduction; • 細胞增殖; • positive regulation of mitotic nuclear division; • positive regulation of trophectodermal cell proliferation; • positive regulation of glycogen biosynthetic process; • positive regulation of fibroblast proliferation; • ERK1 and ERK2 cascade; • negative regulation of extrinsic apoptotic signaling pathway; • cell activation; • negative regulation of oocyte development; • positive regulation of transcription, DNA-templated; • bone mineralization involved in bone maturation; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of MAPK cascade; • proteoglycan biosynthetic process; • positive regulation of activated T cell proliferation; • positive regulation of epithelial cell proliferation; • negative regulation of release of cytochrome c from mitochondria; • protein stabilization; • myotube cell development; • positive regulation of DNA replication; • myoblast proliferation; • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; • positive regulation of protein secretion; • positive regulation of glycoprotein biosynthetic process; • 基因調節; • phosphatidylinositol-mediated signaling; • positive regulation of smooth muscle cell proliferation; • 肌肉肥大; • Akt/PKB信号通路; • regulation of multicellular organism growth; • positive regulation of cell migration; • platelet degranulation; • positive regulation of calcineurin-NFAT signaling cascade; • positive regulation of phosphatidylinositol 3-kinase signaling; • myoblast differentiation; • glycolate metabolic process; • positive regulation of glycolytic process; • negative regulation of smooth muscle cell apoptotic process; • 訊息傳遞; • positive regulation of transcription by RNA polymerase II; • positive regulation of cell growth involved in cardiac muscle cell development; • positive regulation of cell population proliferation; • positive regulation of osteoblast differentiation; • activation of protein kinase B activity; • insulin-like growth factor receptor signaling pathway; • negative regulation of apoptotic process; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • positive regulation of gene expression; • negative regulation of gene expression; • cellular response to amyloid-beta; • positive regulation of vascular associated smooth muscle cell proliferation; • negative regulation of vascular associated smooth muscle cell apoptotic process; • 白细胞介素-1β产生的负调控; • 腫瘤壞死因子產生的負調控; • negative regulation of neuroinflammatory response; • negative regulation of amyloid-beta formation;
	Sources:Amigo / QuickGO
直系同源
	3479
	16000
	ENSG00000017427
	ENSMUSG00000020053
	P05019
	P05017
	NM_000618; NM_001111283; NM_001111284; NM_001111285
NM_001111274; NM_001111275; NM_001111276; NM_010512; NM_184052;
	NM_001314010
	NP_000609; NP_001104753; NP_001104754; NP_001104755
	NP_001104744; NP_001104745; NP_001104746; NP_001300939; NP_034642
	維基數據
檢視/編輯人類	檢視/編輯小鼠

胰岛素样生长因子1（英語：Insulin-like growth factor 1，IGF-1）也被称为生长调节素C（somatomedin C），是一个由人类基因 IGF1 编码的蛋白质^[6]^[7]。在1970年代，IGF-1也曾经被称为“酸硫化（英语：sulfation）因子”^[8]，並認為其作用为“不受抑制的胰岛样活力”（nonsuppressible insulin-like activity，NSILA）。

IGF-1是一个在三级结构上与胰岛素类似的激素，在儿童成长发育中有重要作用，并持续在成人的合成代谢中起作用。一种人工合成的IGF-1类似物，美卡舍明（英语：mecasermin），用于治疗发育停滞^[9]。

IGF-1蛋白由一个肽链构成，包括70个氨基酸残基和三个分子内二硫键，分子量为7,649道尔顿^[10]。

已经发现,垂体前部的生长激素（GH）分泌受到GH释放激素( GHRH )和生长抑素的调节，GHRH和生长抑素之间的相互作用引起搏动性GH分泌，在青春期最高。GH诱导肝脏中胰岛素样生长因子1的产生，并调节许多其他组织中IGF-1的旁分泌。IGF-1是GH的合成代谢和促有丝分裂活性的介体。

参考文献

^ 與胰岛素样生长因子1相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000017427 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020053 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS. The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum. Genet. 1985, 69 (2): 157–60. PMID 2982726. doi:10.1007/BF00293288.
^ Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL. Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature. 1983, 306 (5943): 609–11. PMID 6358902. doi:10.1038/306609a0.
^ Salmon WD, Daughaday WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. 1957, 49 (6): 825–36. PMID 13429201.
^ Keating GM. Mecasermin. BioDrugs. 2008, 22 (3): 177–88. PMID 18481900. doi:10.2165/00063030-200822030-00004.
^ Rinderknecht E, Humbel RE. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem. 1978, 253 (8): 2769–2776. PMID 632300.

延伸阅读

Butler AA, Yakar S, LeRoith D. Insulin-like growth factor-I: compartmentalization within the somatotropic axis?. News Physiol. Sci. 2002, 17: 82–5. PMID 11909998.
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Camacho-Hübner C, Woods KA, Clark AJ, Savage MO. Insulin-like growth factor (IGF)-I gene deletion. Reviews in endocrine & metabolic disorders. 2003, 3 (4): 357–61. PMID 12424437. doi:10.1023/A:1020957809082.
Dantzer B, Swanson EM. Mediation of vertebrate life histories via insulin-like growth factor-1. Biological Reviews. 2012, 87 (2): 414–429. PMID 21981025. doi:10.1111/j.1469-185X.2011.00204.x.
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外部链接

醫學主題詞表（MeSH）：Insulin-Like+Growth+Factor+I
IGF-1 （页面存档备份，存于互联网档案馆） at Lab Tests Online
IGF-1 （页面存档备份，存于互联网档案馆） recombinant GFP labeled at Protean Ltd. （页面存档备份，存于互联网档案馆）

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[1] 與胰岛素样生长因子1相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000017427 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020053 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2982726-6] Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS. The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum. Genet. 1985, 69 (2): 157–60. PMID 2982726. doi:10.1007/BF00293288.

[pmid6358902-7] Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL. Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature. 1983, 306 (5943): 609–11. PMID 6358902. doi:10.1038/306609a0.

[8] Salmon WD, Daughaday WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. 1957, 49 (6): 825–36. PMID 13429201.

[pmid18481900-9] Keating GM. Mecasermin. BioDrugs. 2008, 22 (3): 177–88. PMID 18481900. doi:10.2165/00063030-200822030-00004.

[pmid632300-10] Rinderknecht E, Humbel RE. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem. 1978, 253 (8): 2769–2776. PMID 632300.

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